No protein is an island. Proteins interact to keep the machinery of the whole organism running. Without protein-protein interactions (PPIs), there would be no biochemical reactions, transmission of messages, immune defenses—in short, no possibility of life. All PPIs in a cell form a complex network critical in health and disease, and require considerable time and resources to decipher with precision.

Researchers led by Sheng Zhong, PhD, professor of bioengineering, University of California, San Diego (USCD), have developed a new technology capable of detecting PPIs among thousands of proteins, in a single experiment.

This tool, called PROPER-seq (protein-protein

This work was done in the lab of Sheng Zhong, PhD, professor of bioengineering, University of California, San Diego.

interaction sequencing), allows researchers to map the protein interaction network in cells in a few weeks, without any special resources such as…

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