Studying the role genes play on basic biology and disease is now easier, faster and more efficient, say researchers at Baylor College of Medicine. They have developed a drug-based genetic platform that enables scientists to track genetic manipulations in the laboratory fruit fly without having to screen thousands of individual flies.

The researchers describe in Cell Reports the fundamentals of this new technology as well as examples of its applications. A companion paper in STAR Protocols shows how to set up, conduct and analyze the experimental procedures involved in this technology. Genetic tools and resources, including a plasmid library, to assist researchers in the implementation of this new methodology into their experimental systems, are freely available.

“The laboratory fruit fly is a widely used animal model in which to study the function of genes and mutations on biological processes, both in health and…

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