Insider buying can be an encouraging signal for potential investors, especially when markets are near all-time highs. Once again, some insiders took advantage of recent public share offerings to add or bolster stakes. Again, biotechnology companies are well represented on this list.

Conventional wisdom says that insiders and 10% owners really only buy shares of a company for one reason — they believe the stock price will rise and they want to profit from it. So insider buying can be an encouraging signal for potential investors, particularly when there is uncertainty in the markets or the markets are near all-time highs.

Note that, with the earnings reporting season still underway, many insiders are prohibited from buying or selling shares. Here are some of the most noteworthy insider purchases that were reported in the past week.

The combined 3.52 million or so Impel Neuropharma Inc (NASDAQ:IMPL) shares that five beneficial owners purchased had an initial public offering price of $15.00 per share. These transactions cost them more than $52.87 million. The stock has traded as high as $15.89 a share since the offering but ended the week at $15.20.

Rain Therapeutics Inc (NASDAQ:RAIN) saw two beneficial owners and a former 10% owner buy into the IPO. The more than 2.02 million shares of this oncology company acquired altogether, at $17.00 apiece, added up to over $34.42 million. The stock ended the week trading at $16.37 per share.

A Knowbe4 Inc (NASDAQ:KNBE) beneficial owner indirectly scooped up almost 1.88 million shares early last week. At the IPO price of $16.00 a share, that totaled about $30.00 million for the security awareness platform provider. The stock has traded as high as $26.98 a share but ended the week at $22.98.

A 10% owner of Beacon Roofing Supply, Inc. (NASDAQ:BECN) added to its stake last week. The more than 563,600 shares indirectly bought at around $53.23 apiece totaled nearly $30.00 million and lifted the stake to about 14.32 million shares. The stock hit a 52-week high of $57.67 on Friday.

New Jersey-based real estate investment trust (REIT) Mack Cali Realty Corp

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